ENFSI DNA WG - STR Population Database

ENFSI DNA WG STR Population Database

The European Network of Forensic Science Institutes (ENFSI) has undertaken an extensive study collecting STR-data from 24 European populations (5700 profiles) using the AMPFLSTR SGM Plus system [6], which has become one of the standard STR multiplexes to be used within Europe for the purpose of constructing national DNA criminal intelligence databases. This allele proportion (frequency) database - further referred to as the 'ENFSI DNA WG STR Population Database' - can be used to calculate match probabilities of DNA profiles from cosmopolitan Caucasian populations across all Europe, regardless of their specific country of origin.

Differences in allele proportions between populations of the different countries have been quantified by estimating Fst [1], showing that the effect is small (Fst is approximately 0.001). Nevertheless, the effect cannot simply be ignored because match probabilities of DNA profiles derived from a European database will tend to be lower than those derived from an appropriate cognate population database. In order to take account of both sampling error and population sub-structuring effects, various methods can be applied including the Balding size bias correction [2], the Balding and Nichols Fst correction [3], and an upper bound of a 95% confidence interval [4], which are summarized among others in a recent publication [5].

The task of this website is to make the ENFSI DNA WG STR Population Database generally available, so that it can be used by forensic laboratories to enable the calculation of a match probability for a sample using the above mentioned adjustment factors.

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